By continuing to use the site, you agree to the use of cookies.
more information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.Positive end-expiratory pressure to prevent post-extubation lung injury.
Post-extubation pulmonary dysfunction (PEP) is a major cause of morbidity and mortality after general anaesthesia. Positive end-expiratory pressure (PEEP) reduces pulmonary epithelial injury during acute lung injury and may prevent PEP. We conducted a randomised, controlled, double-blinded, multicenter trial at 26 centres in Australia and New Zealand. We enrolled adult patients undergoing elective non-cardiac surgery, under general anaesthesia. Patients were allocated randomly to one of four groups receiving a PEEP of 0, 5, 10, or 15 cmH2O applied at the end of expiration. The primary outcome was the time to extubation from the end of anaesthesia. We recorded incidences of PEP, dyspnoea, oxygen desaturation to ac619d1d87
Related links:
Comentarios